COPII mitigates ER stress by promoting formation of ER whorls
نویسندگان
چکیده
منابع مشابه
ER export: public transportation by the COPII coach.
The COPII coat produces ER-derived transport vesicles. Recent findings suggest that the COPII coat is a highly dynamic polymer and that efficient capture of cargo molecules into COPII vesicles depends on several parameters, including export signals, membrane environment, metabolic control and the presence of a repertoire of COPII subunit homologues.
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The transcription factor ATF6 is held as a membrane precursor in the endoplasmic reticulum (ER), and is transported and proteolytically processed in the Golgi apparatus under conditions of unfolded protein response stress. We show that during stress, ATF6 forms an interaction with COPII, the protein complex required for vesicular traffic of cargo proteins from the ER. Using an in vitro budding ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2020
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-020-00416-2